The emerging precision dosing field harnesses the explosion of genomic data and various markers of bodily functions using mathematical modeling to ensure that individuals get the best possible treatment. Precision dosing is a key step toward achieving the goals of precision medicine, a global objective supported by world leaders.
Thus, they react to drugs in different ways. Where τ is the dosing interval for the maintenance dose, and k is the terminal elimination rate constant.Įvery patient is different. The loading dose can be determined using the following equation: The loading dose rapidly achieves the therapeutic response and subsequent doses maintain the response. If therapeutic effects are needed quickly, and the drug has a long half-life, one can use a loading dose to achieve therapeutic levels on the first dose. For drugs with rapid elimination and short half-life values, this is not a problem however drugs with slow elimination could require days or weeks to achieve steady-state. ing dose a comparatively large dose given at the beginning of treatment to start getting the effect of a drug, especially one with slow clearance, thus requiring a long period to achieve stable blood levels without a high initial dose. 1 A loading dose is most useful for drugs that are eliminated from the body relatively slowly, i.e.
To achieve steady-state, you need approximately 5-7 half-lives of the drug. Loading dose In pharmacokinetics, a loading dose is an initial higher dose of a drug that may be given at the beginning of a course of treatment before dropping down to a lower maintenance dose. The following table illustrates how long it will take to achieve steady-state relative to the half-life: # of half-lives A substance added to something else a filler. A weight placed on something else a burden. The time it takes for a drug to reach steady-state is a function of the elimination half-life of the drug. Loading dose synonyms, Loading dose pronunciation, Loading dose translation, English dictionary definition of Loading dose. Drug therapy in chronic disease situations requires systemic drug levels to reach target steady-state levels for maximum safety and efficacy.